Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50335681 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_714872 (CHEMBL1663818) |
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IC50 | 140±n/a nM |
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Citation | Caldwell, JJ; Welsh, EJ; Matijssen, C; Anderson, VE; Antoni, L; Boxall, K; Urban, F; Hayes, A; Raynaud, FI; Rigoreau, LJ; Raynham, T; Aherne, GW; Pearl, LH; Oliver, AW; Garrett, MD; Collins, I Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem54:580-90 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50335681 |
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n/a |
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Name | BDBM50335681 |
Synonyms: | (S)-4-fluoro-2-(7-(2-methoxyethoxy)-4-(pyrrolidin-3-ylamino)quinazolin-2-yl)phenol | CHEMBL1650126 |
Type | Small organic molecule |
Emp. Form. | C21H23FN4O3 |
Mol. Mass. | 398.4307 |
SMILES | COCCOc1ccc2c(N[C@H]3CCNC3)nc(nc2c1)-c1cc(F)ccc1O |r| |
Structure |
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