Reaction Details |
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Target | Serine/threonine-protein kinase Chk2 |
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Ligand | BDBM50335684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_714871 (CHEMBL1663817) |
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IC50 | 3.00±n/a nM |
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Citation | Caldwell, JJ; Welsh, EJ; Matijssen, C; Anderson, VE; Antoni, L; Boxall, K; Urban, F; Hayes, A; Raynaud, FI; Rigoreau, LJ; Raynham, T; Aherne, GW; Pearl, LH; Oliver, AW; Garrett, MD; Collins, I Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem54:580-90 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk2 |
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Name: | Serine/threonine-protein kinase Chk2 |
Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
Type: | Protein |
Mol. Mass.: | 60908.59 |
Organism: | Homo sapiens (Human) |
Description: | O96017 |
Residue: | 543 |
Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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BDBM50335684 |
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n/a |
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Name | BDBM50335684 |
Synonyms: | 4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL | 4-Fluoro-2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol | CHEMBL1236782 |
Type | Small organic molecule |
Emp. Form. | C23H27FN4O4 |
Mol. Mass. | 442.4833 |
SMILES | COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O |r| |
Structure |
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