Reaction Details |
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Target | Cathepsin S |
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Ligand | BDBM50323244 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_717666 (CHEMBL1670797) |
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IC50 | 7.2±n/a nM |
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Citation | Arbuckle, W; Baugh, M; Belshaw, S; Bennett, DJ; Bruin, J; Cai, J; Cameron, KS; Claxton, C; Dempster, M; Everett, K; Fradera, X; Hamilton, W; Jones, PS; Kinghorn, E; Long, C; Martin, I; Robinson, J; Westwood, P 1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka. Bioorg Med Chem Lett21:932-5 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin S |
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Name: | Cathepsin S |
Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
Type: | Protein |
Mol. Mass.: | 37507.38 |
Organism: | Homo sapiens (Human) |
Description: | P25774 |
Residue: | 331 |
Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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BDBM50323244 |
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n/a |
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Name | BDBM50323244 |
Synonyms: | 6-(4-(3-(4-ethylpiperazin-1-yl)propoxy)-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile | CHEMBL1209145 |
Type | Small organic molecule |
Emp. Form. | C24H27F3N6O |
Mol. Mass. | 472.506 |
SMILES | CCN1CCN(CCCOc2ccc(cc2C(F)(F)F)-c2cc3n(C)cnc3c(n2)C#N)CC1 |
Structure |
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