| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50336487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_716905 (CHEMBL1670884) |
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| Ki | 6700±n/a nM |
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| Citation |  Durdagi, S; Sentürk, M; Ekinci, D; Balaydin, HT; Göksu, S; Küfrevioglu, ÖI; Innocenti, A; Scozzafava, A; Supuran, CT Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site. Bioorg Med Chem19:1381-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50336487 |
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| n/a |
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| Name | BDBM50336487 |
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| Synonyms: | 3,4-Dimethoxy-benzoic acid | 3,4-dimethoxybenzoic acid | CHEMBL118903 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10O4 |
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| Mol. Mass. | 182.1733 |
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| SMILES | COc1ccc(cc1OC)C(O)=O |
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| Structure | 
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