| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50337186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_726319 (CHEMBL1687307) |
|---|
| IC50 | 39±n/a nM |
|---|
| Citation |  Sweis, RF; Hunt, JA; Kallashi, F; Hammond, ML; Chen, Y; Eveland, SS; Guo, Q; Hyland, SA; Milot, DP; Cumiskey, AM; Latham, M; Rosa, R; Peterson, L; Sparrow, CP; Wright, SD; Anderson, MS; Sinclair, PJ 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy. Bioorg Med Chem Lett21:1890-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50337186 |
|---|
| n/a |
|---|
| Name | BDBM50337186 |
|---|
| Synonyms: | 4-(5-cyano-7-isopropylbenzo[d]oxazol-2-yl)-N-((1-(5-m-tolylpyridin-2-yl)piperidin-4-yl)methyl)benzamide | CHEMBL1684863 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H35N5O2 |
|---|
| Mol. Mass. | 569.6954 |
|---|
| SMILES | CC(C)c1cc(cc2nc(oc12)-c1ccc(cc1)C(=O)NCC1CCN(CC1)c1ccc(cn1)-c1cccc(C)c1)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
