| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
|---|
| Ligand | BDBM50337910 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_726954 (CHEMBL1686743) |
|---|
| IC50 | 8500±n/a nM |
|---|
| Citation |  Shao, L; Hewitt, MC; Wang, F; Malcolm, SC; Ma, J; Campbell, JE; Campbell, UC; Engel, SR; Spicer, NA; Hardy, LW; Schreiber, R; Spear, KL; Varney, MA Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor. Bioorg Med Chem Lett21:1434-7 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2D6 |
|---|
| Name: | Cytochrome P450 2D6 |
|---|
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55774.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10635 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
|---|
| BDBM50337910 |
|---|
| n/a |
|---|
| Name | BDBM50337910 |
|---|
| Synonyms: | (+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine | 1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine | CHEMBL1684045 | CHEMBL1684057 | US10562878, Compound 108 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H21Cl2N |
|---|
| Mol. Mass. | 286.24 |
|---|
| SMILES | CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
