Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Dipeptidyl peptidase 2 | ||
Ligand | BDBM50338473 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_728290 (CHEMBL1687447) | ||
IC50 | 3600±n/a nM | ||
Citation | Chen, P; Caldwell, CG; Ashton, W; Wu, JK; He, H; Lyons, KA; Thornberry, NA; Weber, AE Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors. Bioorg Med Chem Lett21:1880-6 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 2 | |||
Name: | Dipeptidyl peptidase 2 | ||
Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase | ||
Type: | Protein | ||
Mol. Mass.: | 54339.29 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9UHL4 | ||
Residue: | 492 | ||
Sequence: |
| ||
BDBM50338473 | |||
n/a | |||
Name | BDBM50338473 | ||
Synonyms: | CHEMBL1683107 | trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methyl-1H-indole-3-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27F2N3O | ||
Mol. Mass. | 411.4875 | ||
SMILES | CN([C@H]1CC[C@@H](CC1)[C@H](N)Cc1cc(F)ccc1F)C(=O)c1c[nH]c2ccccc12 |r,wU:8.9,2.1,wD:5.4,(52.49,-23.15,;52.49,-21.61,;51.16,-20.83,;49.82,-21.6,;48.49,-20.83,;48.5,-19.29,;49.82,-18.51,;51.16,-19.29,;47.16,-18.53,;47.16,-16.99,;45.83,-19.3,;44.5,-18.53,;44.49,-16.98,;43.16,-16.22,;43.15,-14.68,;41.83,-16.99,;41.82,-18.53,;43.16,-19.3,;43.16,-20.84,;53.82,-20.84,;53.83,-19.3,;55.16,-21.61,;55.32,-23.14,;56.82,-23.46,;57.59,-22.13,;59.09,-21.82,;59.57,-20.36,;58.54,-19.22,;57.05,-19.53,;56.57,-20.98,)| | ||
Structure |