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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50338733 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_726917 (CHEMBL1686706) | ||
| IC50 | 12±n/a nM | ||
| Citation |  Roach, SL; Higuchi, RI; Hudson, AR; Vassar, A; Grant, VH; Lamer, R; Hooper, C; Rungta, D; Syka, PM; Mais, DE; Marschke, KB; Zhi, L Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation. Bioorg Med Chem Lett21:1658-62 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
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| BDBM50338733 | |||
| n/a | |||
| Name | BDBM50338733 | ||
| Synonyms: | (+/-)-(3R,4S)-6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate | CHEMBL1684341 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H22ClF2N3O2 | ||
| Mol. Mass. | 433.879 | ||
| SMILES | CNC(=O)O[C@@H]1[C@@H](C)c2c(F)c(c(F)cc2NC1(C)C)-c1cccc2c(Cl)c[nH]c12 |r,wU:5.4,wD:6.6,(8.99,-9.44,;7.66,-8.67,;6.32,-9.44,;6.32,-10.98,;4.99,-8.66,;3.65,-9.43,;2.31,-8.65,;2.31,-7.11,;.98,-9.43,;-.35,-8.66,;-.36,-7.12,;-1.68,-9.43,;-1.68,-10.98,;-3.02,-11.75,;-.35,-11.75,;.98,-10.97,;2.31,-11.74,;3.65,-10.98,;5.19,-10.97,;3.64,-12.51,;-3.02,-8.66,;-3.01,-7.12,;-4.34,-6.35,;-5.68,-7.12,;-5.67,-8.68,;-6.8,-9.72,;-8.31,-9.41,;-6.16,-11.11,;-4.64,-10.93,;-4.34,-9.43,)| | ||
| Structure | 
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