Reaction Details | |||
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Target | Glucocorticoid receptor | ||
Ligand | BDBM50338732 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_726913 (CHEMBL1686702) | ||
Ki | 3±n/a nM | ||
Citation | Roach, SL; Higuchi, RI; Hudson, AR; Vassar, A; Grant, VH; Lamer, R; Hooper, C; Rungta, D; Syka, PM; Mais, DE; Marschke, KB; Zhi, L Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation. Bioorg Med Chem Lett21:1658-62 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucocorticoid receptor | |||
Name: | Glucocorticoid receptor | ||
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 85656.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P04150 | ||
Residue: | 777 | ||
Sequence: |
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BDBM50338732 | |||
n/a | |||
Name | BDBM50338732 | ||
Synonyms: | (+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinolin-3-yl methylcarbamate | CHEMBL1684230 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23F2N3O2 | ||
Mol. Mass. | 399.4337 | ||
SMILES | CNC(=O)O[C@@H]1[C@@H](C)c2c(NC1(C)C)cc(F)c(c2F)-c1cccc2cc[nH]c12 |r,wU:5.4,wD:6.6,(14.22,-7.79,;12.89,-7.01,;11.56,-7.78,;11.55,-9.32,;10.22,-7.01,;8.89,-7.77,;7.55,-7,;7.55,-5.46,;6.22,-7.77,;6.21,-9.32,;7.54,-10.09,;8.89,-9.32,;9.65,-10.66,;10.43,-9.33,;4.88,-10.09,;3.55,-9.32,;2.22,-10.09,;3.55,-7.78,;4.88,-7.01,;4.88,-5.47,;2.22,-7.01,;2.22,-5.47,;.89,-4.7,;-.44,-5.47,;-.44,-7.02,;-1.57,-8.06,;-.93,-9.45,;.59,-9.28,;.9,-7.78,)| | ||
Structure |