| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
|---|
| Ligand | BDBM50338810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_727043 (CHEMBL1686967) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Napier, SE; Letourneau, JJ; Ansari, N; Auld, DS; Baker, J; Best, S; Campbell-Wan, L; Chan, JH; Craighead, M; Desai, H; Goan, KA; Ho, KK; Hulskotte, EG; MacSweeney, CP; Milne, R; Morphy, JR; Neagu, I; Ohlmeyer, MH; Peeters, AW; Presland, J; Riviello, C; Ruigt, GS; Thomson, FJ; Zanetakos, HA; Zhao, J; Webb, ML Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists. Bioorg Med Chem Lett21:1871-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1b receptor |
|---|
| Name: | Vasopressin V1b receptor |
|---|
| Synonyms: | AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46985.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47901 |
|---|
| Residue: | 424 |
|---|
| Sequence: | MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLG
QLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQG
SGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVG
GGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSV
QMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQ
PRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAE
TIIF
|
|
|
|---|
| BDBM50338810 |
|---|
| n/a |
|---|
| Name | BDBM50338810 |
|---|
| Synonyms: | CHEMBL1684573 | N-isopropyl-2-(2-(3-methoxyphenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)acetamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H36N4O4 |
|---|
| Mol. Mass. | 492.6098 |
|---|
| SMILES | COc1cccc(c1)-c1nc2ccc(OCCCN3CCCCC3)cc2c(=O)n1CC(=O)NC(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
