| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain-2 |
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| Ligand | BDBM50339250 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_736241 (CHEMBL1693385) |
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| IC50 | 43300±n/a nM |
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| Citation |  Praveen Kumar, S; Gut, J; Guedes, RC; Rosenthal, PJ; Santos, MM; Moreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem46:927-33 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain-2 |
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| Name: | Falcipain-2 |
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| Synonyms: | n/a |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.57 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50339250 |
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| n/a |
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| Name | BDBM50339250 |
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| Synonyms: | (Z/E)-(S)-2-((5-chloro-2-oxoindolin-3-ylidene)methylamino)-N-isopentyl-3-phenylpropanamide | CHEMBL1689610 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26ClN3O2 |
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| Mol. Mass. | 411.924 |
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| SMILES | CC(C)CCNC(=O)[C@H](Cc1ccccc1)N=CC1C(=O)Nc2ccc(Cl)cc12 |r,w:17.18| |
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| Structure | 
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