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TargetFalcipain-2
LigandBDBM50339267
Substrate/Competitorn/a
Meas. Tech.ChEMBL_736241
IC50>50000±n/a nM
Citation Praveen Kumar SGut JGuedes RCRosenthal PJSantos MMMoreira R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem 46:927-33 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Falcipain-2
Name:Falcipain-2
Synonyms:n/a
Type:Enzyme
Mol. Mass.:55912.57
Organism:Plasmodium falciparum
Description:n/a
Residue:484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339267
n/a
NameBDBM50339267
Synonyms:(Z/E)-3-((3-(7-chloroquinolin-4-ylamino)propylamino)methylene)indolin-2-one | CHEMBL1687962
TypeSmall organic molecule
Emp. Form.C21H19ClN4O
Mol. Mass.378.855
SMILESClc1ccc2c(NCCCN=CC3C(=O)Nc4ccccc34)ccnc2c1 |w:11.11|
Structure
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