| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine proteinase falcipain 3 |
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| Ligand | BDBM50339253 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_736242 (CHEMBL1693386) |
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| IC50 | >50000±n/a nM |
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| Citation |  Praveen Kumar, S; Gut, J; Guedes, RC; Rosenthal, PJ; Santos, MM; Moreira, R Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem46:927-33 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine proteinase falcipain 3 |
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| Name: | Cysteine proteinase falcipain 3 |
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| Synonyms: | Cysteine protease falcipain-3 |
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| Type: | Protein |
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| Mol. Mass.: | 56666.98 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q9NAW4 |
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| Residue: | 492 |
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| Sequence: | MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNEN
NKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMN
MNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNK
KYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGP
FKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVG
SVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSN
LPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECG
AAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTC
SIGTEAYVPLLE
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| BDBM50339253 |
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| n/a |
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| Name | BDBM50339253 |
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| Synonyms: | (Z/E)-(S)-2-((6-chloro-2-oxoindolin-3-ylidene)methylamino)-N-isopentyl-4-methylpentanamide | CHEMBL1689605 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28ClN3O2 |
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| Mol. Mass. | 377.908 |
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| SMILES | CC(C)CCNC(=O)[C@H](CC(C)C)N=CC1C(=O)Nc2cc(Cl)ccc12 |r,w:14.14| |
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| Structure | 
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