Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50339811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_735656 (CHEMBL1693471) |
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IC50 | 15±n/a nM |
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Citation | Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors. Bioorg Med Chem19:1866-80 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
Type: | Enzyme |
Mol. Mass.: | 44141.72 |
Organism: | Homo sapiens (Human) |
Description: | Purified recombinant human 11beta-HSD2. |
Residue: | 405 |
Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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BDBM50339811 |
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n/a |
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Name | BDBM50339811 |
Synonyms: | (3beta,18beta,20beta)-N-Hydroxy-N-methyl-[3-(1,2,4-oxadiazole-5(2H)-one)]-11-oxo-olean-12-en-29-amide | CHEMBL1689282 |
Type | Small organic molecule |
Emp. Form. | C33H49N3O6 |
Mol. Mass. | 583.7587 |
SMILES | CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](Oc6nc(=O)o[nH]6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 |r,c:15| |
Structure |
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