Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Glucocorticoid receptor | ||
Ligand | BDBM50340665 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_739896 (CHEMBL1762956) | ||
EC50 | 70±n/a nM | ||
Citation | Hudson, AR; Higuchi, RI; Roach, SL; Valdez, LJ; Adams, ME; Vassar, A; Rungta, D; Syka, PM; Mais, DE; Marschke, KB; Zhi, L Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation. Bioorg Med Chem Lett21:1654-7 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Glucocorticoid receptor | |||
Name: | Glucocorticoid receptor | ||
Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 85656.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P04150 | ||
Residue: | 777 | ||
Sequence: |
| ||
BDBM50340665 | |||
n/a | |||
Name | BDBM50340665 | ||
Synonyms: | 5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-yl)-2,3-dihydroquinolin-4(1H)-one O-tert-butyl oxime | CHEMBL1762202 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27F2N3O | ||
Mol. Mass. | 411.4875 | ||
SMILES | Cc1c[nH]c2c(cccc12)-c1c(F)cc2NC(C)(C)C\C(=N/OC(C)(C)C)c2c1F |(3.75,-23.11,;5.09,-23.89,;5.72,-25.3,;7.25,-25.14,;7.58,-23.63,;8.91,-22.86,;8.91,-21.31,;7.58,-20.54,;6.25,-21.31,;6.24,-22.85,;10.24,-23.63,;10.23,-25.17,;8.9,-25.94,;11.55,-25.94,;12.88,-25.19,;14.21,-25.96,;15.55,-25.21,;16.87,-24.43,;16.87,-25.97,;15.56,-23.67,;14.23,-22.88,;14.24,-21.34,;15.58,-20.58,;15.58,-19.05,;16.92,-18.29,;14.26,-18.27,;15.57,-17.51,;12.9,-23.64,;11.57,-22.87,;11.57,-21.33,)| | ||
Structure |