| Reaction Details |
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 | Report a problem with these data |
| Target | Antrax lethal toxin |
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| Ligand | BDBM50340757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_740261 |
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| Ki | 0.39±n/a nM |
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| Citation |  Kim S; Jiao GS; Moayeri M; Crown D; Cregar-Hernandez L; McKasson L; Margosiak SA; Leppla SH; Johnson AT Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy. Bioorg Med Chem Lett 21:2030-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Antrax lethal toxin |
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| Name: | Antrax lethal toxin |
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| Synonyms: | Anthrax lethal factor | lethal factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93758.56 |
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| Organism: | Bacillus anthracis |
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| Description: | ChEMBL_1460338 |
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| Residue: | 809 |
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| Sequence: | MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEE
RNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGD
ITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNV
YYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLE
QNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLAR
YEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSS
DFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYD
INQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLT
ATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSP
DTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNG
RFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHE
FGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHST
DHAERLKVQKNAPKTFQFINDQIKFIINS
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| BDBM50340757 |
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| n/a |
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| Name | BDBM50340757 |
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| Synonyms: | (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoro-3-methylbenzylamino)-N-hydroxyhexanamide | CHEMBL1760316 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30F2N2O2 |
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| Mol. Mass. | 404.4933 |
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| SMILES | Cc1cc(CNCCCC[C@@H](Cc2cc(C)c(F)c(C)c2)C(=O)NO)ccc1F |r| |
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| Structure | 
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