Ki Summary

Reaction Details

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Target

Hemagglutinin-neuraminidase

Ligand

BDBM50341449

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_741750 (CHEMBL1769849)

IC50

1600000±n/a nM

Citation

Nishino, R; Ikeda, K; Hayakawa, T; Takahashi, T; Suzuki, T; Sato, M Syntheses of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1. Bioorg Med Chem19:2418-27 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hemagglutinin-neuraminidase

Name:

Hemagglutinin-neuraminidase

Synonyms:

n/a

Type:

PROTEIN

Mol. Mass.:

64031.12

Organism:

Human parainfluenza virus 1

Description:

ChEMBL_741750

Residue:

575

Sequence:

MAEKGKTNSSYWSTTRNDNSTVNTYIDTPAGKTHIWLLIATTMHTILSFIIMILCIDLII
KQDTCMKTNIITISSMNESAKTIKETITELIRQEVISRTINIQSSVQSGIPILLNKQSRD
LTQLIEKSCNRQELAQICENTNAIHHADGISPLDPHDFWRCPVGEPLLSDNPNISLLPGP
SLLSGSTTISGCVRLPSLSIGDAIYAYSSNLITQGCADIGKSYQVLQLGYISLNSDMYPD
LNPVISHTYDINDNRKSCSVIAAGTRGYQLCSLPTVNETTDYSSEGIEDLVFDILDLKGK
TKSHRYKNEDITFDHPFSAMYPSVGSGIKIENTLIFLGYGGLTTPLQGDTKCVTNRCANV
NQSVCNDALKITWRLKKRQVNVLIRINNYLSDRPKIVVETIPITQNYLGAEGRLLKLGKK
IYIYTRSSGWHSHLQIGSLDINNPMTIKWAPHEVLSRPGNQDCNWYNRCPRECISGVYTD
AYPLSPDAVNVATTTLYANTSRVNPTIMYSNTSEIINMLRLKNVQLEAAYTTTSCITHFG
KGYCFHIVEINQTSLNTLQPMLFKTSIPKICKITS

BDBM50341449

n/a

Name

BDBM50341449

Synonyms:

5-Acetamido-2,6-anhydro-3,5-dideoxy-4-[2-(4-fluorophenyl)-N'-(methylsulfonyl)acetimidamido]-D-glycero-Dgalacto-non-2-enonic acid | CHEMBL1767332

Type

Small organic molecule

Emp. Form.

C20H26FN3O9S

Mol. Mass.

503.499

SMILES

CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O)N=C(Cc1ccc(F)cc1)NS(C)(=O)=O |r,w:20.21,c:6|

Structure