Reaction Details |
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Target | Poly [ADP-ribose] polymerase 2 |
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Ligand | BDBM50341870 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_743712 (CHEMBL1767526) |
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IC50 | 7000±n/a nM |
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Citation | Sunderland, PT; Woon, EC; Dhami, A; Bergin, AB; Mahon, MF; Wood, PJ; Jones, LA; Tully, SR; Lloyd, MD; Thompson, AS; Javaid, H; Martin, NM; Threadgill, MD 5-Benzamidoisoquinolin-1-ones and 5-(κ-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J Med Chem54:2049-59 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Poly [ADP-ribose] polymerase 2 |
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Name: | Poly [ADP-ribose] polymerase 2 |
Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 2 | ADPRT-2 | ARTD2 | Adprt2 | Adprtl2 | Aspartl2 | DNA ADP-ribosyltransferase PARP2 | NAD(+) ADP-ribosyltransferase 2 | PARP-2 | PARP2_MOUSE | Parp2 | Poly (ADP-ribose) Polymerase-2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (Parp2) | Poly [ADP-ribose] polymerase-2 | Poly[ADP-ribose] synthase 2 | Poly[ADP-ribose] synthetase 2 | Protein poly-ADP-ribosyltransferase PARP2 | mPARP-2 | pADPRT-2 | poly-ADP-ribose polymerase 2 (PARP2) |
Type: | n/a |
Mol. Mass.: | 63409.97 |
Organism: | Mus musculus (Mouse) |
Description: | Alexis Biochemicals, Cat. no. ALX-201-064-C020 |
Residue: | 559 |
Sequence: | MAPRRQRSGSGRRVLNEAKKVDNGNKATEDDSPPGKKMRTCQRKGPMAGGKDADRTKDNR
DSVKTLLLKGKAPVDPECAAKLGKAHVYCEGDDVYDVMLNQTNLQFNNNKYYLIQLLEDD
AQRNFSVWMRWGRVGKTGQHSLVTCSGDLNKAKEIFQKKFLDKTKNNWEDRENFEKVPGK
YDMLQMDYAASTQDESKTKEEETLKPESQLDLRVQELLKLICNVQTMEEMMIEMKYDTKR
APLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALVEACNEFYTRIPHDFGLSIPPVIRTE
KELSDKVKLLEALGDIEIALKLVKSERQGLEHPLDQHYRNLHCALRPLDHESNEFKVISQ
YLQSTHAPTHKDYTMTLLDVFEVEKEGEKEAFREDLPNRMLLWHGSRLSNWVGILSHGLR
VAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPK
AQGLLRGKHSTKGMGKMAPSPAHFITLNGSTVPLGPASDTGILNPEGYTLNYNEFIVYSP
NQVRMRYLLKIQFNFLQLW
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BDBM50341870 |
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n/a |
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Name | BDBM50341870 |
Synonyms: | 5-(Thiophene-2-carboxamido)isoquinolin-1-one | CHEMBL1767058 |
Type | Small organic molecule |
Emp. Form. | C14H10N2O2S |
Mol. Mass. | 270.306 |
SMILES | O=C(Nc1cccc2c1cc[nH]c2=O)c1cccs1 |
Structure |
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