| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM50342308 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744057 (CHEMBL1768207) |
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| IC50 | 2300±n/a nM |
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| Citation |  De, SK; Barile, E; Chen, V; Stebbins, JL; Cellitti, JF; Machleidt, T; Carlson, CB; Yang, L; Dahl, R; Pellecchia, M Design, synthesis, and structure-activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase. Bioorg Med Chem19:2582-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM50342308 |
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| n/a |
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| Name | BDBM50342308 |
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| Synonyms: | 2-(2-(2-methoxy-5-methylphenyl)acetamido)thiophene-3-carboxamide | CHEMBL1767251 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N2O3S |
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| Mol. Mass. | 304.364 |
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| SMILES | COc1ccc(C)cc1CC(=O)Nc1sccc1C(N)=O |
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| Structure | 
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