Reaction Details | |||
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Target | Neuropeptide Y receptor type 1 | ||
Ligand | BDBM50342726 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_744205 (CHEMBL1771962) | ||
Ki | 5±n/a nM | ||
Citation | Griffith, DA; Hargrove, DM; Maurer, TS; Blum, CA; De Lombaert, S; Inthavongsay, JK; Klade, LE; Mack, CM; Rose, CR; Sanders, MJ; Carpino, PA Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorg Med Chem Lett21:2641-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuropeptide Y receptor type 1 | |||
Name: | Neuropeptide Y receptor type 1 | ||
Synonyms: | NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 44399.07 | ||
Organism: | Homo sapiens (Human) | ||
Description: | NPY-Y1 NPY1R HUMAN::P25929 | ||
Residue: | 384 | ||
Sequence: |
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BDBM50342726 | |||
n/a | |||
Name | BDBM50342726 | ||
Synonyms: | CHEMBL1771262 | N1-(3-(2,6-dichloro-4-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl)-N2-(tetrahydro-2H-pyran-4-yl)propane-1,2-diamine | ||
Type | Small organic molecule | ||
Emp. Form. | C23H29Cl2N5O2 | ||
Mol. Mass. | 478.415 | ||
SMILES | COc1cc(Cl)c(-c2c(C)nn3c(NCC(C)NC4CCOCC4)cc(C)nc23)c(Cl)c1 |(34.35,-35.54,;35.89,-35.52,;36.65,-34.18,;35.86,-32.85,;36.62,-31.51,;35.84,-30.19,;38.16,-31.51,;38.91,-30.17,;38.01,-28.91,;36.47,-28.91,;38.92,-27.66,;40.39,-28.14,;41.72,-27.38,;41.71,-25.84,;43.04,-25.06,;44.38,-25.83,;44.38,-27.37,;45.71,-25.06,;47.04,-25.84,;47.02,-27.38,;48.34,-28.16,;49.69,-27.4,;49.7,-25.86,;48.37,-25.07,;43.05,-28.14,;43.06,-29.69,;44.39,-30.46,;41.72,-30.46,;40.39,-29.69,;38.94,-32.82,;40.48,-32.8,;38.2,-34.16,)| | ||
Structure |