Reaction Details |
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Target | Solute carrier family 5 member 4 |
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Ligand | BDBM50342888 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745217 (CHEMBL1772493) |
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IC50 | 1.11±n/a nM |
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Citation | Mascitti, V; Maurer, TS; Robinson, RP; Bian, J; Boustany-Kari, CM; Brandt, T; Collman, BM; Kalgutkar, AS; Klenotic, MK; Leininger, MT; Lowe, A; Maguire, RJ; Masterson, VM; Miao, Z; Mukaiyama, E; Patel, JD; Pettersen, JC; Préville, C; Samas, B; She, L; Sobol, Z; Steppan, CM; Stevens, BD; Thuma, BA; Tugnait, M; Zeng, D; Zhu, T Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem54:2952-60 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Solute carrier family 5 member 4 |
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Name: | Solute carrier family 5 member 4 |
Synonyms: | Low affinity sodium-glucose cotransporter | Na(+)/glucose cotransporter 3 | SAAT1 | SC5A4_HUMAN | SGLT3 | SLC5A4 | Sodium/glucose cotransporter 3 | Solute carrier family 5 member 4 |
Type: | PROTEIN |
Mol. Mass.: | 72452.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_764617 |
Residue: | 659 |
Sequence: | MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFL
AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIY
IKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLA
IFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNAT
PSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQR
CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVG
CTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK
ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRV
NEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLV
TLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLK
KAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
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BDBM50342888 |
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n/a |
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Name | BDBM50342888 |
Synonyms: | (1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphenyl]-1-(hydroxymethyl)-6,8-dioxa-bicyclo[3.2.1]octane-2,3,4-triol | CHEMBL1770245 |
Type | Small organic molecule |
Emp. Form. | C23H28O7 |
Mol. Mass. | 416.4642 |
SMILES | CCOc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| |
Structure |
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