| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50343023 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_744294 (CHEMBL1772151) |
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| Ki | 0.9±n/a nM |
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| Citation |  Meduna, SP; Savall, BM; Cai, H; Edwards, JP; Thurmond, RL; McGovern, PM Triamino pyrimidines and pyridines as histamine H(4) receptor modulators. Bioorg Med Chem Lett21:3113-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50343023 |
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| n/a |
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| Name | BDBM50343023 |
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| Synonyms: | (R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-yl)pyridine-2,6-diamine | CHEMBL1770973 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25N5 |
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| Mol. Mass. | 275.3925 |
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| SMILES | CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1 |r| |
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| Structure | 
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