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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 1 | ||
| Ligand | BDBM50333368 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_744512 (CHEMBL1772533) | ||
| Ki | 0.870000±n/a nM | ||
| Citation |  Yamasaki, T; Fujinaga, M; Yoshida, Y; Kumata, K; Yui, J; Kawamura, K; Hatori, A; Fukumura, T; Zhang, MR Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1. Bioorg Med Chem Lett21:2998-3001 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 1 | |||
| Name: | Metabotropic glutamate receptor 1 | ||
| Synonyms: | GPRC1A | GRM1 | GRM1_HUMAN | MGLUR1 | Metabotropic Glutamate 1a | metabotropic glutamate 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 132358.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13255 | ||
| Residue: | 1194 | ||
| Sequence: |
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| BDBM50333368 | |||
| n/a | |||
| Name | BDBM50333368 | ||
| Synonyms: | CHEMBL1645348 | [11C]-cis-(3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexyl)methanone | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25NO2 | ||
| Mol. Mass. | 311.418 | ||
| SMILES | CCc1cc2cc(ccc2nc1C)C(=O)[C@@H]1CC[C@@H](CC1)OC |r,wU:15.16,18.23,(4.3,-15,;2.96,-14.24,;1.63,-15.01,;.3,-14.25,;-1.03,-15.02,;-2.36,-14.25,;-3.69,-15.02,;-3.7,-16.56,;-2.37,-17.33,;-1.03,-16.56,;.3,-17.33,;1.64,-16.56,;2.97,-17.33,;-5.02,-14.25,;-5.02,-12.71,;-6.36,-15.01,;-7.69,-14.23,;-9.01,-15.01,;-9.01,-16.55,;-7.69,-17.31,;-6.36,-16.55,;-10.35,-17.32,;-11.68,-16.55,)| | ||
| Structure | 
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