Reaction Details |
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Target | Glucose-dependent insulinotropic receptor |
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Ligand | BDBM50343442 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_746178 (CHEMBL1775792) |
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EC50 | 23±n/a nM |
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Citation | Semple, G; Ren, A; Fioravanti, B; Pereira, G; Calderon, I; Choi, K; Xiong, Y; Shin, YJ; Gharbaoui, T; Sage, CR; Morgan, M; Xing, C; Chu, ZL; Leonard, JN; Grottick, AJ; Al-Shamma, H; Liang, Y; Demarest, KT; Jones, RM Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett21:3134-41 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucose-dependent insulinotropic receptor |
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Name: | Glucose-dependent insulinotropic receptor |
Synonyms: | G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor |
Type: | Protein |
Mol. Mass.: | 36901.49 |
Organism: | Homo sapiens (Human) |
Description: | Q8TDV5 |
Residue: | 335 |
Sequence: | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
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BDBM50343442 |
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n/a |
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Name | BDBM50343442 |
Synonyms: | CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate |
Type | Small organic molecule |
Emp. Form. | C21H24FN5O5S |
Mol. Mass. | 477.509 |
SMILES | CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O |
Structure |
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