Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50343486 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_746462 (CHEMBL1776378) |
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IC50 | 19±n/a nM |
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Citation | Bühler, S; Goettert, M; Schollmeyer, D; Albrecht, W; Laufer, SA Chiral sulfoxides as metabolites of 2-thioimidazole-based p38a mitogen-activated protein kinase inhibitors: enantioselective synthesis and biological evaluation. J Med Chem54:3283-97 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50343486 |
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n/a |
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Name | BDBM50343486 |
Synonyms: | 4-(4-(4-fluorophenyl)-2-((R)-methylsulfinyl)-1H-imidazol-5-yl)-N-((S)-3-methylbutan-2-yl)pyridin-2-amine | CHEMBL1773510 |
Type | Small organic molecule |
Emp. Form. | C20H23FN4OS |
Mol. Mass. | 386.486 |
SMILES | CC(C)[C@H](C)Nc1cc(ccn1)-c1nc([nH]c1-c1ccc(F)cc1)[S@@](C)=O |r| |
Structure |
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