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TargetMitogen-activated protein kinase 14
LigandBDBM50343504
Substrate/Competitorn/a
Meas. Tech.ChEMBL_746462 (CHEMBL1776378)
IC50 11±n/a nM
Citation Bühler, S; Goettert, M; Schollmeyer, D; Albrecht, W; Laufer, SA Chiral sulfoxides as metabolites of 2-thioimidazole-based p38a mitogen-activated protein kinase inhibitors: enantioselective synthesis and biological evaluation. J Med Chem54:3283-97 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50343504
n/a
NameBDBM50343504
Synonyms:(R)-N-cyclohexyl-4-(4-(4-fluorophenyl)-2-(isopropylsulfinyl)-1H-imidazol-5-yl)pyridin-2-amine | CHEMBL1773503
TypeSmall organic molecule
Emp. Form.C23H27FN4OS
Mol. Mass.426.55
SMILESCC(C)[S@@](=O)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(NC2CCCCC2)c1 |r|
Structure
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