| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome c oxidase subunit 1 |
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| Ligand | BDBM50343721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_746069 (CHEMBL1775456) |
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| IC50 | 130±n/a nM |
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| Citation |  Wang, L; Hubert, JA; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; MacNeil, DJ; Weber, AE; Edmondson, SD Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists. Bioorg Med Chem Lett21:2911-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome c oxidase subunit 1 |
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| Name: | Cytochrome c oxidase subunit 1 |
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| Synonyms: | COI | COX1_HUMAN | COXI | MT-CO1 | MTCO1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57042.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_746069 |
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| Residue: | 513 |
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| Sequence: | MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA
HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA
GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ
TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH
PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN
SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKR
KVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
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| BDBM50343721 |
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| n/a |
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| Name | BDBM50343721 |
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| Synonyms: | 3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)pyrimidine-2-carbonyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL1774043 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H29FN4O4 |
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| Mol. Mass. | 576.6169 |
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| SMILES | COc1ccc(cc1)-c1cnc(nc1-c1ccc(C)cc1F)C(=O)N1CCN(CC1)c1cc(C(O)=O)c2ccccc2c1 |
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| Structure | 
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