| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily E member 1 |
|---|
| Ligand | BDBM50343721 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_746072 (CHEMBL1775459) |
|---|
| IC50 | >9000±n/a nM |
|---|
| Citation |  Wang, L; Hubert, JA; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; MacNeil, DJ; Weber, AE; Edmondson, SD Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists. Bioorg Med Chem Lett21:2911-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily E member 1 |
|---|
| Name: | Potassium voltage-gated channel subfamily E member 1 |
|---|
| Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 14676.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1456351 |
|---|
| Residue: | 129 |
|---|
| Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
|
|
|
|---|
| BDBM50343721 |
|---|
| n/a |
|---|
| Name | BDBM50343721 |
|---|
| Synonyms: | 3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)pyrimidine-2-carbonyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL1774043 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H29FN4O4 |
|---|
| Mol. Mass. | 576.6169 |
|---|
| SMILES | COc1ccc(cc1)-c1cnc(nc1-c1ccc(C)cc1F)C(=O)N1CCN(CC1)c1cc(C(O)=O)c2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
