Reaction Details |
| Report a problem with these data |
Target | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
---|
Ligand | BDBM50344033 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_748479 (CHEMBL1780332) |
---|
IC50 | 19.6±n/a nM |
---|
Citation | DeNinno, MP; Wright, SW; Visser, MS; Etienne, JB; Moore, DE; Olson, TV; Rocke, BN; Andrews, MP; Zarbo, C; Millham, ML; Boscoe, BP; Boyer, DD; Doran, SD; Houseknecht, KL 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability. Bioorg Med Chem Lett21:3095-8 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
---|
Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
Synonyms: | PDE8B | PDE8B_HUMAN | Phosphodiesterase 8 | Phosphodiesterase 8B |
Type: | PROTEIN |
Mol. Mass.: | 98984.88 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_876321 |
Residue: | 885 |
Sequence: | MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASG
PPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEV
RIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEII
VIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFME
NSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFER
MMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVK
ITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDV
KSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLE
ILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITI
NDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAW
FQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHP
GRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAI
IDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCA
DVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYF
ITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
|
|
|
BDBM50344033 |
---|
n/a |
---|
Name | BDBM50344033 |
Synonyms: | CHEMBL1780102 | trans-(3R,5R)-5-ethyl-1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-(((S)-tetrahydrofuran-2-yl)methyl)piperidine-3-carboxamide |
Type | Small organic molecule |
Emp. Form. | C24H33N3O3 |
Mol. Mass. | 411.5371 |
SMILES | CC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NC[C@@H]1CCCO1 |r| |
Structure |
|