| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
|---|
| Ligand | BDBM50344560 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_748115 (CHEMBL1781745) |
|---|
| Ki | 76±n/a nM |
|---|
| Citation |  Mincione, F; Benedini, F; Biondi, S; Cecchi, A; Temperini, C; Formicola, G; Pacileo, I; Scozzafava, A; Masini, E; Supuran, CT Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action. Bioorg Med Chem Lett21:3216-21 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 4 |
|---|
| Name: | Carbonic anhydrase 4 |
|---|
| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35037.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22748 |
|---|
| Residue: | 312 |
|---|
| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
|
|
|
|---|
| BDBM50344560 |
|---|
| n/a |
|---|
| Name | BDBM50344560 |
|---|
| Synonyms: | 4-(4-sulfamoylphenoxy)butyl nitrate | CHEMBL1778438 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H14N2O6S |
|---|
| Mol. Mass. | 290.293 |
|---|
| SMILES | NS(=O)(=O)c1ccc(OCCCCO[N+]([O-])=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
