Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-2

Ligand

BDBM50345243

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_752074 (CHEMBL1786238)

IC50

110±n/a nM

Citation

Xiang, Y; Hirth, B; Asmussen, G; Biemann, HP; Bishop, KA; Good, A; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Liu, J; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg Med Chem Lett21:3050-6 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-2

Name:

Serine/threonine-protein kinase pim-2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

34185.93

Organism:

Homo sapiens (Human)

Description:

Q9P1W9

Residue:

311

Sequence:

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

BDBM50345243

n/a

Name

BDBM50345243

Synonyms:

CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)pyrazin-2-yl)benzofuran-2-carboxylic acid

Type

Small organic molecule

Emp. Form.

C19H20N4O3

Mol. Mass.

352.3871

SMILES

N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O |r,wD:4.7,1.0,(37.06,-16.23,;38.39,-17,;38.39,-18.54,;39.73,-19.31,;41.06,-18.53,;41.05,-16.99,;39.73,-16.23,;42.39,-19.29,;43.72,-18.52,;43.71,-16.97,;45.05,-16.2,;46.38,-16.97,;46.38,-18.51,;45.05,-19.28,;47.71,-19.28,;47.7,-20.82,;49.04,-21.59,;50.38,-20.81,;51.84,-21.28,;52.74,-20.03,;51.83,-18.79,;50.37,-19.27,;49.03,-18.51,;54.28,-20.02,;55.06,-21.35,;55.04,-18.68,)|

Structure