| Reaction Details |
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 | Report a problem with these data |
| Target | Unconventional myosin-Va |
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| Ligand | BDBM50345502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_751031 (CHEMBL1786816) |
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| IC50 | 1200±n/a nM |
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| Citation |  Preller, M; Chinthalapudi, K; Martin, R; Knolker, HJ; Manstein, DJ Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study. J Med Chem54:3675-85 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Unconventional myosin-Va |
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| Name: | Unconventional myosin-Va |
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| Synonyms: | Dilute myosin heavy chain, non-muscle | MYO5A | MYO5A_CHICK | Myosin heavy chain p190 | Myosin-V | Myosin-Va |
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| Type: | PROTEIN |
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| Mol. Mass.: | 212421.50 |
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| Organism: | Gallus gallus |
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| Description: | ChEMBL_751031 |
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| Residue: | 1829 |
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| Sequence: | MAASELYTKYARVWIPDPEEVWKSAELLKDYKPGDKVLQLRLEEGKDLEYCLDPKTKELP
PLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYG
EDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF
ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMR
TYLLEKSRVVFQAEEERNYHIFYQLCASAALPEFKTLRLGNANYFHYTKQGGSPVIDGID
DAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIF
CDLMGVDYEEMAHWLCHRKLATATETYIKPISKLHAINARDALAKHIYANLFNWIVDHVN
KALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKE
QIPWTLIDFYDNQPCINLIEAKMGVLDLLDEECKMPKGSDDTWAQKLYNTHLNKCALFEK
PRLSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSKKFKLLPELFQDEEKAI
SPTSATPSGRVPLSRTPVKPAKARPGQTSKEHKKTVGHQFRNSLHLLMETLNATTPHYVR
CIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDV
LSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKIRADKLRAACIRIQKTIRG
WLMRKKYMRMRRAAITIQRYVRGHQARCYATFLRRTRAAIIIQKFQRMYVVRKRYQCMRD
ATIALQALLRGYLVRNKYQMMLREHKSIIIQKHVRGWLARVHYHRTLKAIVYLQCCYRRM
MAKRELKKLKIEARSVERYKKLHIGLENKIMQLQRKIDEQNKEYKSLLEKMNNLEITYST
ETEKLRSDVERLRMSEEEAKNATNRVLSLQEEIAKLRKELHQTQTEKKTIEEWADKYKHE
TEQLVSELKEQNTLLKTEKEELNRRIHDQAKEITETMEKKLVEETKQLELDLNDERLRYQ
NLLNEFSRLEERYDDLKDEMNLMVSIPKPGHKRTDSTHSSNESEYTFSSEITEAEDLPLR
MEEPSEKKAPLDMSLFLKLQKRVTELEQEKQSLQDELDRKEEQALRAKAKEEERPPIRGA
ELEYESLKRQELESENKKLKNELNELQKALTETRAPEVTAPGAPAYRVLLDQLTSVSEEL
EVRKEEVLILRSQLVSQKEAIQPKEDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETN
RLLESQLQSQKKSHENELESLRGEIQSLKEENNRQQQLLAQNLQLPPEARIEASLQHEIT
RLTNENLDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNI
PRKEKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDD
QKVRSLLTSTINGIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTPRQN
EHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGL
RKRTSSIADEGTYTLDSIIRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAVTLNNLLL
RKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDEDAEA
ICSMCNALTTAQIVKVLNLYTPVNEFEERVLVSFIRTIQLRLRDRKDSPQLLMDAKHIFP
VTFPFNPSSLALETIQIPASLGLGFISRV
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| BDBM50345502 |
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| n/a |
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| Name | BDBM50345502 |
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| Synonyms: | CHEMBL1235156 | pentabromopseudilin |
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| Type | Small organic molecule |
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| Emp. Form. | C10H4Br5NO |
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| Mol. Mass. | 553.665 |
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| SMILES | Oc1c(Br)cc(Br)cc1-c1[nH]c(Br)c(Br)c1Br |
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| Structure | 
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