Reaction Details |
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Target | Sodium/hydrogen exchanger 1 |
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Ligand | BDBM50345911 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_749801 (CHEMBL1787961) |
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IC50 | 3.6±n/a nM |
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Citation | Xu, WT; Jin, N; Xu, J; Xu, YG; Wang, QJ; You, QD Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors. Bioorg Med Chem Lett19:3283-7 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/hydrogen exchanger 1 |
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Name: | Sodium/hydrogen exchanger 1 |
Synonyms: | NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 91655.00 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_862370 |
Residue: | 820 |
Sequence: | MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGD
VTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMK
IGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYF
LPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISA
VDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFL
SFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMAL
IASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVIS
TLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPM
CDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIED
ICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGK
IPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVA
DPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPV
ITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTD
DVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
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BDBM50345911 |
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n/a |
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Name | BDBM50345911 |
Synonyms: | CHEMBL1783852 | CHEMBL1789669 | N-(diaminomethylene)-3-nitro-4-((4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)methyl)benzamide hydrochloride |
Type | Small organic molecule |
Emp. Form. | C23H30N6O6 |
Mol. Mass. | 486.5209 |
SMILES | COc1ccc(CN2CCN(Cc3ccc(cc3[N+]([O-])=O)C(=O)NC(N)=N)CC2)c(OC)c1OC |
Structure |
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