| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1 |
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| Ligand | BDBM50345917 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749801 (CHEMBL1787961) |
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| IC50 | 4.48±n/a nM |
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| Citation |  Xu, WT; Jin, N; Xu, J; Xu, YG; Wang, QJ; You, QD Design, synthesis and biological evaluation of novel substituted benzoylguanidine derivatives as potent Na+/H+ exchanger inhibitors. Bioorg Med Chem Lett19:3283-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 1 |
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| Name: | Sodium/hydrogen exchanger 1 |
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| Synonyms: | NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91655.00 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_862370 |
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| Residue: | 820 |
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| Sequence: | MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGD
VTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMK
IGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYF
LPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISA
VDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFL
SFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMAL
IASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVIS
TLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPM
CDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIED
ICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGK
IPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVA
DPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPV
ITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTD
DVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
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| BDBM50345917 |
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| n/a |
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| Name | BDBM50345917 |
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| Synonyms: | CHEMBL1783857 | N-(diaminomethylene)-3-(N-methylsulfamoyl)-4-(1-(4-(2,3,4-trimethoxybenzyl)piperazin-1-yl)ethyl)benzamide hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36N6O6S |
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| Mol. Mass. | 548.655 |
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| SMILES | CNS(=O)(=O)c1cc(ccc1C(C)N1CCN(Cc2ccc(OC)c(OC)c2OC)CC1)C(=O)NC(N)=N |
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| Structure | 
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