| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transcription factor p65 |
|---|
| Ligand | BDBM50346334 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_749381 (CHEMBL1785171) |
|---|
| IC50 | 2900±n/a nM |
|---|
| Citation |  Ren, Y; Matthew, S; Lantvit, DD; Ninh, TN; Chai, H; Fuchs, JR; Soejarto, DD; de Blanco, EJ; Swanson, SM; Kinghorn, AD Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues. J Nat Prod74:1117-25 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transcription factor p65 |
|---|
| Name: | Transcription factor p65 |
|---|
| Synonyms: | NFKB3 | Nuclear factor NF-kappa-B | Nuclear factor NF-kappa-B p65 subunit | RELA | TF65_HUMAN | v-rel reticuloendotheliosis viral oncogene homolog A isoform 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60211.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q04206 |
|---|
| Residue: | 551 |
|---|
| Sequence: | MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
|
|
|
|---|
| BDBM50346334 |
|---|
| n/a |
|---|
| Name | BDBM50346334 |
|---|
| Synonyms: | 1,3,7-trihydroxy-2,4-diisoprenylxanthone | CHEMBL1782240 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24O5 |
|---|
| Mol. Mass. | 380.4337 |
|---|
| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c2oc3ccc(-[#8])cc3c(=O)c2c1-[#8] |
|---|
| Structure | 
|
|---|
Search and Browse
