| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50346445 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_751314 (CHEMBL1787992) |
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| IC50 | 7020±n/a nM |
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| Citation |  Berrade, L; Aisa, B; Ramirez, MJ; Galiano, S; Guccione, S; Moltzau, LR; Levy, FO; Nicoletti, F; Battaglia, G; Molinaro, G; Aldana, I; Monge, A; Perez-Silanes, S Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action. J Med Chem54:3086-90 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70168.43 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P31652 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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| BDBM50346445 |
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| n/a |
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| Name | BDBM50346445 |
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| Synonyms: | 1-Benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl-(S)-pyrrolidin-3-ylamino)propan-1-one | CHEMBL1782804 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20F3N3O3S |
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| Mol. Mass. | 463.473 |
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| SMILES | [O-][N+](=O)c1ccc(N2CC[C@@H](C2)NCCC(=O)c2csc3ccccc23)c(c1)C(F)(F)F |r| |
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| Structure | 
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