| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-25 |
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| Ligand | BDBM50346800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_753772 (CHEMBL1799653) |
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| IC50 | 76±n/a nM |
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| Citation |  Nuti, E; Casalini, F; Santamaria, S; Gabelloni, P; Bendinelli, S; Da Pozzo, E; Costa, B; Marinelli, L; La Pietra, V; Novellino, E; Margarida Bernardo, M; Fridman, R; Da Settimo, F; Martini, C; Rossello, A Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem46:2617-29 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-25 |
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| Name: | Matrix metalloproteinase-25 |
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| Synonyms: | Leukolysin | MMP-25 | MMP20 | MMP25 | MMP25_HUMAN | MMPL1 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP) |
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| Type: | Protein |
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| Mol. Mass.: | 62564.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NPA2 |
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| Residue: | 562 |
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| Sequence: | MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD
AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL
TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ
DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG
LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ
PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW
EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF
SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG
AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA
GRWPAPIPLLLLPLLVGGVASR
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| BDBM50346800 |
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| n/a |
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| Name | BDBM50346800 |
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| Synonyms: | CHEMBL1795859 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N3O4S2 |
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| Mol. Mass. | 521.651 |
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| SMILES | CCCCc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NO |r| |
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| Structure | 
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