Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetRenin
LigandBDBM50346994
Substrate/Competitorn/a
Meas. Tech.ChEMBL_753403
IC50 0.600000±n/a nM
Citation Chen ACampeau LCCauchon EChefson ADucharme YDubé DFalgueyret JPFournier PAGagné SGrimm EHan YHoule RHuang JQLacombe PLaliberté SLévesque JFLiu SMacDonald DMackay BMcKay DPercival MDRegan CRegan HSt-Jacques RToulmond S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorg Med Chem Lett 21:3970-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50346994
n/a
NameBDBM50346994
Synonyms:CHEMBL1795912
TypeSmall organic molecule
Emp. Form.C25H31Cl2N3O3
Mol. Mass.492.438
SMILESCOCCc1cc(Cl)c(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccn(C)c(=O)c2)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: