| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidine kinase |
|---|
| Ligand | BDBM50348876 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_757933 (CHEMBL1809350) |
|---|
| IC50 | 38000±n/a nM |
|---|
| Citation |  Quintiliani, M; Persoons, L; Solaroli, N; Karlsson, A; Andrei, G; Snoeck, R; Balzarini, J; McGuigan, C Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides. Bioorg Med Chem19:4338-45 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidine kinase |
|---|
| Name: | Thymidine kinase |
|---|
| Synonyms: | KITH_FHV1 | TK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 38921.74 |
|---|
| Organism: | Feline herpesvirus 1 |
|---|
| Description: | ChEMBL_757933 |
|---|
| Residue: | 343 |
|---|
| Sequence: | MASGTIPVQNEEIIKSQVNTVRIYIDGAYGIGKSLTAKYLVRADENRPGYTYYFPEPMLY
WRSLFETDVVGGIYAVQDRKRRGELSAEDAAYITAHYQARFAAPYLLLHSRLSTITGYQK
VVCEEHPDVTLIIDRHPLASLVCFPLARYFVGDMTLGSVLSLMATLPREPPGGNLVVTTL
NIEEHLKRLRGRSRTGEQIDMKLIHALRNVYMMLVHTKKFLTKNTSWRDGWGKLKIFSHY
ERNRLVETTIVSDSTESDLCDTLFSVFKARELSDQNGDLLDMHAWVLDGLMETLQNLQIF
TLNLEGTPDECAAALGALRQDMDMTFIAACDMHRISEALTIYH
|
|
|
|---|
| BDBM50348876 |
|---|
| n/a |
|---|
| Name | BDBM50348876 |
|---|
| Synonyms: | CHEMBL1807153 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H9F2IN2O5 |
|---|
| Mol. Mass. | 390.0794 |
|---|
| SMILES | OC[C@H]1O[C@@H](n2cc(I)c(=O)[nH]c2=O)C(F)(F)[C@@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
