| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50348874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_757931 (CHEMBL1809348) |
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| IC50 | 22000±n/a nM |
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| Citation |  Quintiliani, M; Persoons, L; Solaroli, N; Karlsson, A; Andrei, G; Snoeck, R; Balzarini, J; McGuigan, C Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides. Bioorg Med Chem19:4338-45 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1 | TK | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40902.47 |
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| Organism: | Human herpesvirus 1 |
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| Description: | ChEMBL_208027 |
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| Residue: | 376 |
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| Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
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| BDBM50348874 |
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| n/a |
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| Name | BDBM50348874 |
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| Synonyms: | CHEMBL1807155 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H9ClF2N2O5 |
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| Mol. Mass. | 298.628 |
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| SMILES | OC[C@H]1O[C@@H](n2cc(Cl)c(=O)[nH]c2=O)C(F)(F)[C@@H]1O |r| |
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| Structure | 
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