| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 2 |
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| Ligand | BDBM50349344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_760112 (CHEMBL1810435) |
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| Ki | 53±n/a nM |
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| Citation |  Sielaff, F; Böttcher-Friebertshäuser, E; Meyer, D; Saupe, SM; Volk, IM; Garten, W; Steinmetzer, T Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett21:4860-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 2 |
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| Name: | Transmembrane protease serine 2 |
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| Synonyms: | PRSS10 | Serine protease 10 | TMPRSS2 | TMPS2_HUMAN | Transmembrane protease serine 2 catalytic chain | Transmembrane protease serine 2 non-catalytic chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53867.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_760112 |
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| Residue: | 492 |
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| Sequence: | MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
TDWIYRQMRADG
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| BDBM50349344 |
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| n/a |
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| Name | BDBM50349344 |
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| Synonyms: | CHEMBL1809250 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H35N7O3S |
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| Mol. Mass. | 501.645 |
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| SMILES | [#6]-[#6]-[#6](-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7])-[#6](=O)-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]S(=O)(=O)[#6]-c1ccccc1 |r| |
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| Structure | 
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