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TargetPotassium voltage-gated channel subfamily A member 5
LigandBDBM50349984
Substrate/Competitorn/a
Meas. Tech.ChEMBL_762202 (CHEMBL1816273)
IC50>33300±n/a nM
Citation Bregman, HBerry, LBuchanan, JLChen, ADu, BFeric, EHierl, MHuang, LImmke, DJanosky, BJohnson, DLi, XLigutti, JLiu, DMalmberg, AMatson, DMcDermott, JMiu, PNguyen, HNPatel, VFWaldon, DWilenkin, BZheng, XMZou, AMcDonough, SIDiMauro, EF Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J Med Chem54:4427-45 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Potassium voltage-gated channel subfamily A member 5
Name:Potassium voltage-gated channel subfamily A member 5
Synonyms:HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:Enzyme
Mol. Mass.:67222.47
Organism:Homo sapiens (Human)
Description:P22460
Residue:613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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BDBM50349984
n/a
NameBDBM50349984
Synonyms:CHEMBL1813048
TypeSmall organic molecule
Emp. Form.C25H27F3N6O3
Mol. Mass.516.5155
SMILESCC(=O)Nc1cccc(Nc2ncnc(n2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C
Structure
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