Reaction Details |
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Target | Poly(ADP-ribose) glycohydrolase |
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Ligand | BDBM50350095 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_760969 (CHEMBL1814966) |
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IC50 | 12000±n/a nM |
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Citation | Steffen, JD; Coyle, DL; Damodaran, K; Beroza, P; Jacobson, MK Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem54:5403-13 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Poly(ADP-ribose) glycohydrolase |
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Name: | Poly(ADP-ribose) glycohydrolase |
Synonyms: | PARG | PARG_HUMAN | Poly(ADP-ribose) glycohydrolase | poly(ADP-ribose) glycohydrolase (PARG) |
Type: | Protein |
Mol. Mass.: | 111107.13 |
Organism: | Homo sapiens (Human) |
Description: | Q86W56 |
Residue: | 976 |
Sequence: | MNAGPGCEPCTKRPRWGAATTSPAASDARSFPSRQRRVLDPKDAHVQFRVPPSSPACVPG
RAGQHRGSATSLVFKQKTITSWMDTKGIKTAESESLDSKENNNTRIESMMSSVQKDNFYQ
HNVEKLENVSQLSLDKSPTEKSTQYLNQHQTAAMCKWQNEGKHTEQLLESEPQTVTLVPE
QFSNANIDRSPQNDDHSDTDSEENRDNQQFLTTVKLANAKQTTEDEQAREAKSHQKCSKS
CDPGEDCASCQQDEIDVVPESPLSDVGSEDVGTGPKNDNKLTRQESCLGNSPPFEKESEP
ESPMDVDNSKNSCQDSEADEETSPGFDEQEDGSSSQTANKPSRFQARDADIEFRKRYSTK
GGEVRLHFQFEGGESRTGMNDLNAKLPGNISSLNVECRNSKQHGKKDSKITDHFMRLPKA
EDRRKEQWETKHQRTERKIPKYVPPHLSPDKKWLGTPIEEMRRMPRCGIRLPLLRPSANH
TVTIRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQ
TALLNKFTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKI
ALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDIN
FNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKPLTRLHV
TYEGTIEENGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIISRLFTEVLDHNEC
LIITGTEQYSEYTGYAETYRWSRSHEDGSERDDWQRRCTEIVAIDALHFRRYLDQFVPEK
MRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYF
TFGDSELMRDIYSMHIFLTERKLTVGDVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAV
ESCAETADHSGQRTGT
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BDBM50350095 |
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n/a |
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Name | BDBM50350095 |
Synonyms: | CHEMBL1813881 |
Type | Small organic molecule |
Emp. Form. | C23H14Cl3NO3 |
Mol. Mass. | 458.721 |
SMILES | Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1 |
Structure |
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