| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Ligand | BDBM50009001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_761392 (CHEMBL1817022) |
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| Ki | 1600±n/a nM |
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| Citation |  Kenyon, V; Rai, G; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Perry, S; Joshi, N; Bougie, JM; Leister, W; Taylor-Fishwick, DA; Nadler, JL; Holinstat, M; Simeonov, A; Maloney, DJ; Holman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem54:5485-97 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
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| Type: | Protein |
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| Mol. Mass.: | 75689.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18054 |
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| Residue: | 663 |
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| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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| BDBM50009001 |
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| n/a |
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| Name | BDBM50009001 |
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| Synonyms: | 5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one | Baicalein | Baicalein, 14 | Baicalein, 8 | CHEMBL8260 | US10252984, Table 2.33 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10O5 |
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| Mol. Mass. | 270.2369 |
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| SMILES | Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1 |
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| Structure | 
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