| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50351944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_766014 (CHEMBL1828143) |
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| IC50 | 279.5±n/a nM |
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| Citation |  Huang, WJ; Chen, CC; Chao, SW; Yu, CC; Yang, CY; Guh, JH; Lin, YC; Kuo, CI; Yang, P; Chang, CI Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors. Eur J Med Chem46:4042-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50351944 |
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| n/a |
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| Name | BDBM50351944 |
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| Synonyms: | CHEMBL1822043 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H36N2O6 |
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| Mol. Mass. | 424.531 |
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| SMILES | CC(C)CCc1c(O)c(CCC(=O)NO)ccc1OCCCCCCCC(=O)NO |
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| Structure | 
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