| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50352990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_767700 (CHEMBL1825812) |
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| IC50 | 590±n/a nM |
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| Citation |  Scheiper, B; Matter, H; Steinhagen, H; Böcskei, Z; Fleury, V; McCort, G Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors. Bioorg Med Chem Lett21:5480-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50352990 |
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| n/a |
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| Name | BDBM50352990 |
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| Synonyms: | CHEMBL1824965 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27FN4O2 |
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| Mol. Mass. | 458.5273 |
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| SMILES | COc1ccc2n(c(Cc3cccc(F)c3C)c(C(=O)N3CCNCC3)c2n1)-c1ccccc1 |
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| Structure | 
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