Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50353643 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_769809 (CHEMBL1831673) |
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IC50 | 171±n/a nM |
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Citation | Ballatore, C; Soper, JH; Piscitelli, F; James, M; Huang, L; Atasoylu, O; Huryn, DM; Trojanowski, JQ; Lee, VM; Brunden, KR; Smith, AB Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. J Med Chem54:6969-83 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50353643 |
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n/a |
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Name | BDBM50353643 |
Synonyms: | CHEMBL1829808 |
Type | Small organic molecule |
Emp. Form. | C22H24ClNO4S |
Mol. Mass. | 433.948 |
SMILES | CCC1C(=O)CC(Cc2cccc(CCNS(=O)(=O)c3ccc(Cl)cc3)c2)C1=O |
Structure |
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