Reaction Details | |||
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Target | Hypoxia-inducible factor 1-alpha | ||
Ligand | BDBM50354131 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_770820 (CHEMBL1837625) | ||
IC50 | 22900±n/a nM | ||
Citation | Huang, W; Huang, R; Attene-Ramos, MS; Sakamuru, S; Englund, EE; Inglese, J; Austin, CP; Xia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett21:5239-43 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Hypoxia-inducible factor 1-alpha | |||
Name: | Hypoxia-inducible factor 1-alpha | ||
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A | ||
Type: | Protein | ||
Mol. Mass.: | 92647.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16665 | ||
Residue: | 826 | ||
Sequence: |
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BDBM50354131 | |||
n/a | |||
Name | BDBM50354131 | ||
Synonyms: | CHEMBL1836182 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H26N4O2 | ||
Mol. Mass. | 426.5102 | ||
SMILES | O=c1n(c(CN2CCNCC2)nc2ccccc12)-c1ccccc1OCc1ccccc1 |(-2.67,4.23,;-2.67,2.7,;-1.33,1.93,;-1.33,.38,;,-.39,;,-1.93,;-1.33,-2.7,;-1.33,-4.23,;,-5.01,;1.33,-4.24,;1.33,-2.7,;-2.67,-.39,;-4,.38,;-5.33,-.39,;-6.67,.38,;-6.67,1.93,;-5.33,2.7,;-4,1.93,;,2.7,;,4.23,;1.33,5.01,;2.67,4.23,;2.67,2.7,;1.33,1.93,;1.33,.38,;2.67,-.38,;4,.38,;5.33,-.38,;6.67,.38,;6.67,1.93,;5.33,2.7,;4,1.93,)| | ||
Structure |