| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM50354232 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_770721 (CHEMBL1837245) |
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| Ki | 4500±n/a nM |
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| Citation |  Sosic, I; Mirkovic, B; Turk, S; Šefaneb, B; Kos, J; Gobec, S Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B. Eur J Med Chem46:4648-56 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM50354232 |
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| n/a |
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| Name | BDBM50354232 |
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| Synonyms: | CHEMBL1836470 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14ClN3OS2 |
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| Mol. Mass. | 375.896 |
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| SMILES | Clc1cccc(CSc2nc(SCc3ccccc3)nc(=O)[nH]2)c1 |
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| Structure | 
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