Reaction Details | |||
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Target | Corticotropin-releasing factor receptor 1 | ||
Ligand | BDBM50354968 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772056 (CHEMBL1837665) | ||
Ki | 14±n/a nM | ||
Citation | Miller, DC; Klute, W; Brown, AD Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles. Bioorg Med Chem Lett21:6108-11 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Corticotropin-releasing factor receptor 1 | |||
Name: | Corticotropin-releasing factor receptor 1 | ||
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 50744.31 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34998 | ||
Residue: | 444 | ||
Sequence: |
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BDBM50354968 | |||
n/a | |||
Name | BDBM50354968 | ||
Synonyms: | CHEMBL1836933 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H27N5O | ||
Mol. Mass. | 377.4827 | ||
SMILES | COc1ccc(c(C)c1)-n1c(C)nc2c(NC(C3CC3)C3CC3)nc(C)nc12 |(20.29,-8.23,;21.04,-6.89,;20.24,-5.57,;18.7,-5.59,;17.91,-4.27,;18.66,-2.93,;20.2,-2.9,;20.94,-1.55,;20.99,-4.21,;17.87,-1.61,;18.78,-.36,;20.32,-.36,;17.87,.9,;16.4,.42,;15.06,1.18,;15.06,2.72,;13.72,3.49,;13.72,5.03,;14.48,6.35,;12.94,6.35,;12.39,2.71,;10.85,2.71,;11.62,1.38,;13.73,.41,;13.73,-1.13,;12.4,-1.9,;15.07,-1.9,;16.4,-1.13,)| | ||
Structure |